Today’s episode is dedicated to PICU applications of lipid emulsion therapy. Join us as we discuss the patient case, symptoms, and treatment. 

Joining us is Dr. Ziad N. Kazzi, Associate Professor of Emergency Medicine at Emory University School of Medicine, Director of the International Toxicology Fellowship Program at Emory, and Assistant Medical Director of the Georgia Poison Center. Dr. Kazzi is also a board member of the American College of Medical Toxicology and current president of the Middle East North Africa Toxicology Association. 

>>Click here to download the PICU card for this episode<<

Show Highlights:

  • Our case: a 14-year-old girl has been admitted to PICU after acute ingestion of the calcium channel blocker Amlodipine in a suicide attempt
  • Symptoms: profound hypotension
  • Acute management: After fluid resuscitation, norepinephrine infusion, and high-dose insulin therapy, lipid emulsion therapy is considered
  • How lipid emulsion therapy began
  • How lipids work in the toxicology realm
  • Applications in PICU for indicators and efficient doses of lipid emulsion therapy
  • Examples of cases that call for lipid emulsion therapy
  • Considerations of propofol as a substitute for lipid emulsion therapy
  • To minimize complications from lipid emulsion therapy, pay attention to dosing guidelines, limit the duration of the infusion, and focus on systemic toxicities
  • Final thoughts: Know when to use (and when not to use) antidotes and be aware of publication bias with any studies


Download the PICU Card for this episode here